A Genetic Porcine Model of Cancer
L.B. Schook , T.V. Collares, W. Hu,Y. Liang, F. M. Rodrigues, L. A. Rund, K. M. Schachtschneider, F.K. Seixas, K. Singh, K.D. Wells, E. M. Walters, R.S. Prather, C.M. Counter
Targeted disruption of CD1d prevents NKT cell development in pigs
G. Yang, B. L. Artiaga, T.J. Hackmann, M.S. Samuel, E.M. Walters, S. Salek-Ardakani, J.P. Driver
New Strains Added
The NSRRC would like to extend “Thank You” to Dr. Bob Petters from North Carolina State University for his generous donation to the NSRRC. Dr. Petters donated 19 different strains to the NSRRC to be used to study Eye disorders.
Use of the CRISPR/Cas9 system to produce genetically
engineered pigs from in vitro-derived oocytes and embryos
Whitworth KM, Lee K, Benne JA, Beaton BP, Spate LD, Murphy SL, Samuel MS, Mao J, O'Gorman C, Walters EM, Murphy CN,
Driver J, Mileham A, McLaren D, Wells KD, Prather RS.
Oct 8, 2014
NSRRC accepts large donation of Transgenic Swine Eye Models.
More details to come later
Engraftment of human iPS and allogeneic porcine cells
into pigs with inactivated RAG2 and accompanying
severe combined immunodeficiency.
Kiho Lee, Deug-Nam Kwon, Toshihiko Ezashia, Yun-Jung Choi, Chankyu Park, Aaron C. Ericsson, Alana N.
Brown, Melissa Samuel, Kwang-wook Park, Eric Walters, Dae Young Kim, Jae-Hwan Kim, Craig L. Franklin,
Clifton N. Murphy, R. Michael Roberts, Randall S. Prather, and Jin-Hoi Kim
Birth of Breast Cancer Model Piglets
April, 9, 2013
Transgenic pig carrying green fluorescent proteasomes.
EL Miles, C O'Gorman, J Zhao, MS Samuel, EM Walters, YJ Yi, M Sutovsky, RS Prather, KD Wells, P Sutovsky.Transgenic pig carrying green fluorescent proteasomes. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6334-9. doi: 10.1073/pnas.1220910110. Epub 2013 Apr 2. PMID: 23550158.
March 18, 2013
Birth of Ubiquitin-NLS-GFP
March 13, 2013
Birth of Ubiquitin-dsTomato
PNAS manuscript accepted details coming soon
Nov 15, 2012
Swine Genome Complete
Link to the companion papers
Oct 1, 2012
Marker Free hDAF-into-GGTA1 Pig
June 8, 2012
Pigs used in Microbiome Studies
May 21, 2012
Birth of New Cancer Model Piglets
April 16, 2012
Birth of New Piglets:
2) Liver Specific Suicide Gene
April 1, 2012
Launch of a New/Updated Website
March 1, 2012
Generation of an inbred miniature pig model of retinitis pigmentosa.
Ross JW, Fernandez de Castro JP, Zhao J, Samuel M, Walters E, Rios C, Bray-Ward P, Jones BW, Marc RE, Wang W, Zhou L, Noel JM, McCall MA, Demarco PJ, Prather RS, Kaplan HJ.
Invest Ophthalmol Vis Sci. 2012 Jan 31;53(1):501-7. Print 2012 Jan.
Swine are the optimal model species for investigation of a large number of human
diseases and have made valuable contributions to almost every field of human medicine.
Swine share anatomic and physiologic characteristics with humans that make them
ideal models for research. In addition, the anatomy and physiology make pig organs
likely candidates for xenotransplantation.
The National Swine Resource and Research Center (NSRRC) was established in 2003
to develop the infrastructure to ensure that biomedical investigators across a variety
of disciplines have access to critically needed swine models of human health and
disease. The NSRRC will also serve as a central resource for reagents, creation
of new genetically modified swine, and information and training related to use of
swine models in biomedical research.
Questions, comments, feedback? Contact the NSRRC at NSRRC@missouri.edu
Web Site Maintained
Phone (573)882-1134 -- Fax (573) 884-4798 -- E-mail
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