for assistance call: 573-882-1134

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February 2016

Publication release

Birth of two potential new models

COL6A

APC

October 2015

Publication release

DNA Methylation supports pig as biomedical model.

September 2015

Publication release

Engineering protein processing of the mammary gland to produce abundant hemophilia B therapy in milk.

Zhao J, Xu W, Ross JW, Walters EM, Butler SP, Whyte JJ, Kelso L, Fatemi M, Vanderslice NC, Giroux K, Spate LD, Samuel MS, Murphy CN, Wells KD, Masiello NC, Prather RS, Velander WH. Engineering protein processing of the mammary gland to produce abundant hemophilia B therapy in milk.

July 2015

Publication release

A Genetic Porcine Model of Cancer

L.B. Schook , T.V. Collares, W. Hu,Y. Liang, F. M. Rodrigues, L. A. Rund, K. M. Schachtschneider, F.K. Seixas, K. Singh, K.D. Wells, E. M. Walters, R.S. Prather, C.M. Counter

Targeted disruption of CD1d prevents NKT cell development in pigs

G. Yang, B. L. Artiaga, T.J. Hackmann, M.S. Samuel, E.M. Walters, S. Salek-Ardakani, J.P. Driver

February 2015

New Strains Added

The NSRRC would like to extend “Thank You” to Dr. Bob Petters from North Carolina State University for his generous donation to the NSRRC. Dr. Petters donated 19 different strains to the NSRRC to be used to study Eye disorders.

November 2014

Publication release

Use of the CRISPR/Cas9 system to produce genetically engineered pigs from in vitro-derived oocytes and embryos

Whitworth KM, Lee K, Benne JA, Beaton BP, Spate LD, Murphy SL, Samuel MS, Mao J, O'Gorman C, Walters EM, Murphy CN, Driver J, Mileham A, McLaren D, Wells KD, Prather RS.

Oct 8, 2014

Press release

NSRRC accepts large donation of Transgenic Swine Eye Models.
More details to come later

May 2014

Publication release

Engraftment of human iPS and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency.

Kiho Lee, Deug-Nam Kwon, Toshihiko Ezashia, Yun-Jung Choi, Chankyu Park, Aaron C. Ericsson, Alana N. Brown, Melissa Samuel, Kwang-wook Park, Eric Walters, Dae Young Kim, Jae-Hwan Kim, Craig L. Franklin, Clifton N. Murphy, R. Michael Roberts, Randall S. Prather, and Jin-Hoi Kim

October 2013

Birth of Breast Cancer Model Piglets

September 2013

ZP3-Cre-GFP

UBC-Tomato

NLS-UBC-eGFP

April, 9, 2013

Publication release

Transgenic pig carrying green fluorescent proteasomes.

EL Miles, C O'Gorman, J Zhao, MS Samuel, EM Walters, YJ Yi, M Sutovsky, RS Prather, KD Wells, P Sutovsky.Transgenic pig carrying green fluorescent proteasomes. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6334-9. doi: 10.1073/pnas.1220910110. Epub 2013 Apr 2. PMID: 23550158.

March 18, 2013

Birth of Ubiquitin-NLS-GFP

March 13, 2013

Birth of Ubiquitin-dsTomato

PNAS manuscript accepted details coming soon

Nov 15, 2012

Swine Genome Complete

Link to the companion papers

Oct 1, 2012

Marker Free hDAF-into-GGTA1 Pig

June 8, 2012

April 1, 2012.

Launch of a New/Updated Website

March 1, 2012.

Publication release

Generation of an inbred miniature pig model of retinitis pigmentosa.

Ross JW, Fernandez de Castro JP, Zhao J, Samuel M, Walters E, Rios C, Bray-Ward P, Jones BW, Marc RE, Wang W, Zhou L, Noel JM, McCall MA, Demarco PJ, Prather RS, Kaplan HJ.

Invest Ophthalmol Vis Sci. 2012 Jan 31;53(1):501-7. Print 2012 Jan.

 

Archived News Links


Submission Application for Creation of
Genetically Modified Pigs

Dear Investigator,

Please use the following form to provide information about the pig line you would like the NSRRC to create.

Please submit the completed form electronically. Completed forms will be reviewed by the NSRRC Steering Committee. Because only a limited amount of funding exists to create models for NIH-funded investigators, only 3 pig lines per year will be approved.

Please complete the following questions. * = required field


APPLICANT INFORMATION:
Investigator: *
Institution:
Department/Bldg/Room:
Postal Address
City:
State/Province:
Zip Code/Postal Code:
Country:
Phone: *
Fax:
Email: *
List current and pending NIH funding:
 
PIG LINE DESIRED:
 
Nature of Mutation:
Desired genetic alteration(s): *
Pig strain on which gene alteration is desired:
Describe expected phenotype:
For what types of research will
the swine model be useful:
Describe the rationale for creating
this model as a swine model rather
than another animal species:
Potential estimate for the
demand for this mutant:
Please provide any additional information about
the desired swine model that may be useful in
understanding the potential value of this model:
Please provide distinguishing characteristics
that make the mutant unique: