for assistance call: 573-882-1134

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November 1, 2016

Updated Publications


October 1, 2016

Publication release

Suggested Guidelines for Tissue Collection

August 1, 2016

Publication release

Birth of potential new model: PAH KO
Donation of a new model: Dr. Monique Lorson, MU donates SMN -/+ animals

February 2016

Publication release

Birth of two potential new models

COL6A

APC

October 2015

Publication release

DNA Methylation supports pig as biomedical model.

September 2015

Publication release

Engineering protein processing of the mammary gland to produce abundant hemophilia B therapy in milk.

Zhao J, Xu W, Ross JW, Walters EM, Butler SP, Whyte JJ, Kelso L, Fatemi M, Vanderslice NC, Giroux K, Spate LD, Samuel MS, Murphy CN, Wells KD, Masiello NC, Prather RS, Velander WH. Engineering protein processing of the mammary gland to produce abundant hemophilia B therapy in milk.

July 2015

Publication release

A Genetic Porcine Model of Cancer

L.B. Schook , T.V. Collares, W. Hu,Y. Liang, F. M. Rodrigues, L. A. Rund, K. M. Schachtschneider, F.K. Seixas, K. Singh, K.D. Wells, E. M. Walters, R.S. Prather, C.M. Counter

Targeted disruption of CD1d prevents NKT cell development in pigs

G. Yang, B. L. Artiaga, T.J. Hackmann, M.S. Samuel, E.M. Walters, S. Salek-Ardakani, J.P. Driver

February 2015

New Strains Added

The NSRRC would like to extend “Thank You” to Dr. Bob Petters from North Carolina State University for his generous donation to the NSRRC. Dr. Petters donated 19 different strains to the NSRRC to be used to study Eye disorders.

November 2014

Publication release

Use of the CRISPR/Cas9 system to produce genetically engineered pigs from in vitro-derived oocytes and embryos

Whitworth KM, Lee K, Benne JA, Beaton BP, Spate LD, Murphy SL, Samuel MS, Mao J, O'Gorman C, Walters EM, Murphy CN, Driver J, Mileham A, McLaren D, Wells KD, Prather RS.

Oct 8, 2014

Press release

NSRRC accepts large donation of Transgenic Swine Eye Models.
More details to come later

May 2014

Publication release

Engraftment of human iPS and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency.

Kiho Lee, Deug-Nam Kwon, Toshihiko Ezashia, Yun-Jung Choi, Chankyu Park, Aaron C. Ericsson, Alana N. Brown, Melissa Samuel, Kwang-wook Park, Eric Walters, Dae Young Kim, Jae-Hwan Kim, Craig L. Franklin, Clifton N. Murphy, R. Michael Roberts, Randall S. Prather, and Jin-Hoi Kim

 

Archived News Links

Strain Availability


To request swine or cryopreserved material from the NSRRC, please contact NSRRC@missouri.edu, at (573) 882-1134.

There are a variety of samples available from the strains listed below: A few examples are fetal fibroblast, fresh and cryopreserved semen, live animals, hearts, femurs, kidneys, liver, Day 50 eyes, and Day 60 fetal hearts. Please inquire about the sample request and availability; we should be able to meet your requests in a timely manner. All NSRRC strain distributions require a NSRRC Outgoing Material Transfer Agreement.

List of Available Strains

Stock # Strain Name Background Affected Gene(s) Genomic Alteration
NSRRC:0001 Truline® Hampshire outbred N/A wildtype
NSRRC:0002 Truline® Duroc outbred N/A wildtype
NSRRC:0003 Truline® Landrace outbred N/A wildtype
NSRRC:0004 Truline® Large White outbred N/A wildtype
NSRRC:0005 Minnesota Mini closed population N/A wildtype
NSRRC:0008 Ossabaw closed population N/A wildtype
NSRRC:0009

GGTA1 knockout;CD55

closed population CD55 and GGTA1 GGTA1 knockout and CD55 transgene
NSRRC:0010 GFP NT5 outbred N/A Transgene: CAG promoter driving eGFP
NSRRC:0011 FAT-1 outbred FAT1 Transgene: expression of hFAT1
NSRRC:0012 Yucatan closed population N/A wildtype
NSRRC:0013 NIH Mini g/g inbred N/A wildtype
NSRRC:0014 NIH Mini c/c inbred N/A wildtype
NSRRC:0015 NIH Mini a/a inbred N/A wildtype
NSRRC:0016 GFP NT92 outbred Green fluorescent Protein Transgene: CAG promoter driving the enhanced green fluorescent protein
NSRRC:0017 Rhodopsin NIHc/c RHO Transgene: Rhodopsin (RHO) P23H substitution
NSRRC:0018 FVIII outbred FVII, FURIN, SERPINA1 Transgenes: Human coagulation factor VIII; Human alpha 1-antitrypsin; Propeptide cleavage enzyme (PACE/FURIN)
NSRRC:0019 FIX outbred FIX, FURIN, VWF Transgenes: Human coagulation factor IX; Human alpha 1-antitrypsin; von Willibrand factor
NSRRC:0020 GFP Yucatan Yucatan Green fluorescent Protein Transgene: CAG promoter driving the enhanced green fluorescent protein
NSRRC:0021 Tie2-eNOS Yucatan NOS3 Transgene: Tie2 promoter driving endothelial Nitrate Oxide Synthase (NOS3)
NSRRC:0022 Tie2-Catalase Yucatan CAT Transgene: Human Catalase (CAT)
NSRRC:0024 GFP-Proteasomes Minnesota Mini PSMA1

Transgene: GFP-Proteasome Fusion Protein (PSMA1)

NSRRC:0025 Multi-Xeno outbred GGTA1, CD39, CD55, CD59

GGTA1 knockout; with three randomly integrated transgenes: human decay-accelerating factor (CD55); CD39; CD59 and thrombomodulin

NSRRC:0026 NLS-CAG-eGFP Minnesota Mini Green Fluorescent Protein

Transgene: CAG promoter driving a Nuclear localized enhanced Green fluorescent Protein

NSRRC:0027 CAG-Tomato Minnesota Mini tdTomato

Transgene: CAG promoter driving tdTomato

NSRRC:0028 ALP-CD outbred CDA Transgene: Alpha fetoprotein (AFP) promoter driving cytidine deaminase (CDA)
NSRRC:0029 ALB-xTK outbred TK1

Transgene: Albumin (ALB) promoter driving Thymidine Kinase (TK1)

NSRRC:0030 ZP3-Cre Minnesota Mini ZP3-CRE-CRE

Transgene: Zona Pecullida 3 (ZP3) promoter driving CRE-eGFP

NSRRC:0031 UBC-Tomato Minnesota Mini tdTomato

Transgene: Ubiquitin C (UBC) promoter driving tdTomato

NSRRC:0032 NLS-UBC-eGFP Minnesota Mini Green Fluorescent Protein

Transgene: Ubiquitin C (UBC) promoter driving Nuclear Localized eGFP

NSRRC:0033 Onco-pig Minnesota Mini KRASG12D and p53R172H

Transgene: CAG LoxP Stop driving KRASG12D and p53R172H

NSRRC:0034 DMD Yucatan DMD

Deletion of Exon 42 of DMD

NSRRC:0035 RAG2 KO Minnesota Mini RAG2

RAG2 Knockout

NSRRC:0036 BRCA knockdown outbred BRCA1

Transgene: CSN2 promoter driving micro RNAs directed against BRAC1 and RASSF1

NSRRC:0037 CD55 into GGTA1 Minnesota Mini GGTA1 and CD55

GGTA1 knockout with a transgene for human decay-accelerating factor (CD55) inserted into GGTA1

NSRRC:0038 CD1D KO outbred CD1D

CD1D knockout

NSRRC:0039 FGF8 outbred FGF8

truncated version of FGF8

NSRRC:0040 ISL1-Cre outbred ISL1

Transgene: ISL1 - tissue specific expression of CRE

NSRRC:0041 wild-type- White line outbred N/A

wildtype

NSRRC:0042 Wild-Type-Purple outbred N/A

wildtype

NSRRC:0043 Wild-type-Green outbred N/A

wildtype

NSRRC:0044 Rhodopsin Pro347Leu-Type 1 outbred RHO

Transgene: Pro347Leu in RHO (Type I) in pubs

NSRRC:0045 Rhodopsin Pro347Leu-Type II outbred RHO

Transgene: Pro347Leu in RHO (Type II)

NSRRC:0046 Rhodopsin Pro347Ser outbred RHO

Transgene: Pro347Ser in RHO

NSRRC:0047 ELOVL4- Line 102 outbred ELOVL4

Transgene: 5 bp deletion in ELOVL4

NSRRC:0048 ELOVL4 Line 912 outbred ELOVL4

Transgene: ELOVL4 Y270X with the enhanced yellow fluorescent protein

NSRRC:0049 ELOVL4- Line 913 outbred ELOVL4

Transgene: ELOVL4 Y270X with the enhanced yellow fluorescent protein

NSRRC:0050 ELOVL4- Line 301 outbred ELOVL4

Transgene: ELOVL4 Y270X with the enhanced yellow fluorescent protein

NSRRC:0051 ELOVL4- Line 303 outbred ELOVL4

Transgene: ELOVL4 Y270X with the enhanced yellow fluorescent protein

NSRRC:0052 ELOVL4- Line 304 outbred ELOVL4

Transgene: ELOVL4 Y270X with the enhanced yellow fluorescent protein

NSRRC:0053 PROML1 - Line 001 outbred PROM1

Transgene: R373C mutation of human PROM1

NSRRC:0054 PROML1- Line 307 outbred PROM1

Transgene: wild type human PROML1

NSRRC:0055 PROML1- Line 905 outbred PROM1

Transgene: wild type human PROML1

NSRRC:0056 PROML1- Line 908 outbred PROM1

Transgene: wild type human PROML1

NSRRC:0057 CTRP outbred C1QTNF5 (CTRP)

Transgene: S163R mutation of pig CTRP (C1QTNF5)

NSRRC:0058 CTRP-Line 2 outbred C1QTNF5 (CTRP)

Transgene: S163R mutation of pig CTRP (C1QTNF5)

NSRRC:0059 Str8 mitochondrial localized eYGFP outbred Enhanced Yellow Fluorescent Protein

Transgene: male germ cell (STR8) tissue specific expression of enhance yellow fluroescent protein (EYFP)

NSRRC:0060 TMPRSS2 outbred TMPRSS2

TMPRSS2 knockout

NSRRC:0061 CD39 and CD55 into GGTA1 Minnesota Mini GGTA1

GGTA1 knockout with human decay-accelerating factor (CD55) and CD39 transgenes inserted into GGTA1

(Click on the Stock # link for additional information.)

PROCESS: