for assistance call: 573-882-1134

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November 1, 2016

Updated Publications


October 1, 2016

Publication release

Suggested Guidelines for Tissue Collection

August 1, 2016

Publication release

Birth of potential new model: PAH KO
Donation of a new model: Dr. Monique Lorson, MU donates SMN -/+ animals

February 2016

Publication release

Birth of two potential new models

COL6A

APC

October 2015

Publication release

DNA Methylation supports pig as biomedical model.

September 2015

Publication release

Engineering protein processing of the mammary gland to produce abundant hemophilia B therapy in milk.

Zhao J, Xu W, Ross JW, Walters EM, Butler SP, Whyte JJ, Kelso L, Fatemi M, Vanderslice NC, Giroux K, Spate LD, Samuel MS, Murphy CN, Wells KD, Masiello NC, Prather RS, Velander WH. Engineering protein processing of the mammary gland to produce abundant hemophilia B therapy in milk.

July 2015

Publication release

A Genetic Porcine Model of Cancer

L.B. Schook , T.V. Collares, W. Hu,Y. Liang, F. M. Rodrigues, L. A. Rund, K. M. Schachtschneider, F.K. Seixas, K. Singh, K.D. Wells, E. M. Walters, R.S. Prather, C.M. Counter

Targeted disruption of CD1d prevents NKT cell development in pigs

G. Yang, B. L. Artiaga, T.J. Hackmann, M.S. Samuel, E.M. Walters, S. Salek-Ardakani, J.P. Driver

February 2015

New Strains Added

The NSRRC would like to extend “Thank You” to Dr. Bob Petters from North Carolina State University for his generous donation to the NSRRC. Dr. Petters donated 19 different strains to the NSRRC to be used to study Eye disorders.

November 2014

Publication release

Use of the CRISPR/Cas9 system to produce genetically engineered pigs from in vitro-derived oocytes and embryos

Whitworth KM, Lee K, Benne JA, Beaton BP, Spate LD, Murphy SL, Samuel MS, Mao J, O'Gorman C, Walters EM, Murphy CN, Driver J, Mileham A, McLaren D, Wells KD, Prather RS.

Oct 8, 2014

Press release

NSRRC accepts large donation of Transgenic Swine Eye Models.
More details to come later

May 2014

Publication release

Engraftment of human iPS and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency.

Kiho Lee, Deug-Nam Kwon, Toshihiko Ezashia, Yun-Jung Choi, Chankyu Park, Aaron C. Ericsson, Alana N. Brown, Melissa Samuel, Kwang-wook Park, Eric Walters, Dae Young Kim, Jae-Hwan Kim, Craig L. Franklin, Clifton N. Murphy, R. Michael Roberts, Randall S. Prather, and Jin-Hoi Kim

 

Archived News Links

Research Emphasis/Objectives

The National Swine Resource and Research Center (NSRRC) was established in 2003 to develop the infrastructure to ensure that biomedical investigators across a variety of disciplines have access to critically needed swine models of human health and disease. The NSRRC will also serve as a central resource for reagents, creation of new genetically modified swine, and information and training related to use of swine models in biomedical research.

Services Provided:

• Animals

  • Swine are imported into the resource center, rederived to a pathogen-free status, and gametes and embryos are cryopreserved to prevent future loss. Swine models are then available for distribution to biomedical investigators at a nominal cost.

• Biological Materials

  • Tissues/organs

• Health Monitoring

  • The NSRRC performs on-going health monitoring to assure maintenance of a pathogen-free status

• Cryopreservation

  • The NSRRC cryopreserves and stores gametes, embryos and somatic cells to prevent loss of valuable models

• Research

  • Improved techniques for cryopreservation of pig reproductive cells and tissues
  • Improved methods for the detection and elimination of microbial pathogens in pigs
  • Development of improved methods for the production of transgenic and knockout pigs

• PI-Driven Model Creation

  • The center creates custom models for NIH-funded investigators. Requests are evaluated by the Steering Committee and prioritized. Animals are first distributed to the requesting principal investigators, and then made available to others.